CBI Keynote NEURO - Plenary Talk by John CRYAN - Gut Feelings: The Microbiome as a Key Regulator of Brain & Behaviour Across the Lifespan

The microbiota-gut-brain axis is emerging as a research area of increasing interest for those investigating the biological and physiological basis of neurodevelopmental, age-related, and neuropsychiatric disorders. The routes of communication between the gut and brain include the vagus nerve, the immune system, via the enteric nervous system or via microbial metabolites such as short chain fatty acids. Studies in animal models have been key in delineating that neurodevelopment and the programming of an appropriate stress response is dependent on the microbiota. Developmentally, a variety of factors can impact the microbiota in early life including mode of birth delivery, antibiotic exposure, mode of nutritional provision, infection, stress as well as host genetics. Finally, studies examining the translation of these effects from animals to humans are currently ongoing. Further studies will focus on understanding the mechanisms underlying such brain effects and developing nutritional and microbial-based psychobiotic intervention strategies and how these interact with various systems in the body across the lifespan.